WIAS Technical Report No. 11, (2008)

Structural adaptive smoothing for single-subject analysis in SPM: The aws4SPM-toolbox


  • Hoffmann, Devy
  • Tabelow, Karsten
    ORCID: 0000-0003-1274-9951

2010 Mathematics Subject Classification

  • 62P10 92C55




There exists a variety of software tools for analyzing functional Magnetic Resonance Imaging data. A very popular one is the freely available SPM package by the Functional Imaging Laboratory at the Wellcome Department of Imaging Neuroscience. In order to enhance the signal-to-noise ratio it provides the possibility to smooth the data in a pre-processing step by a Gaussian filter. However, this comes at the cost of reducing the effective resolution. In a series of recent papers it has been shown, that using a structural adaptive smoothing algorithm based on the Propagation-Separation method allows for enhanced signal detection while preserving the shape and spatial extent of the activation areas. Here, we describe our implementation of this algorithm as a toolbox for SPM.

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