WIAS Preprint No. 2613, (2019)

Well-posedness and regularity for a fractional tumor growth model



Authors

  • Colli, Pierluigi
  • Gilardi, Gianni
  • Sprekels, Jürgen

2010 Mathematics Subject Classification

  • 35Q92 92C17 35K35 35K90

Keywords

  • Fractional operators, Cahn--Hilliard systems, well-posedness, regularity of solutions, tumor growth models

DOI

10.20347/WIAS.PREPRINT.2613

Abstract

In this paper, we study a system of three evolutionary operator equations involving fractional powers of selfadjoint, monotone, unbounded, linear operators having compact resolvents. This system constitutes a generalization of a phase field system of Cahn--Hilliard type modelling tumor growth that has been proposed in Hawkins-Daarud et al. (Int. J. Numer. Math. Biomed. Eng. 28 (2012), 3--24) and investigated in recent papers co-authored by the present authors and E. Rocca. The model consists of a Cahn--Hilliard equation for the tumor cell fraction φ, coupled to a reaction-diffusion equation for a function S representing the nutrient-rich extracellular water volume fraction. Effects due to fluid motion are neglected. The generalization investigated in this paper is motivated by the possibility that the diffusional regimes governing the evolution of the different constituents of the model may be of different (e.g., fractional) type. Under rather general assumptions, well-posedness and regularity results are shown. In particular, by writing the equation governing the evolution of the chemical potential in the form of a general variational inequality, also singular or nonsmooth constributions of logarithmic or of double obstacle type to the energy density can be admitted.

Appeared in

  • Adv. Math. Sci. Appl., 28 (2019), pp. 343--375.

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