WIAS Preprint No. 1382, (2008)

Structural adaptive smoothing in diffusion tensor imaging: The R package dti



Authors

  • Polzehl, Jörg
    ORCID: 0000-0001-7471-2658
  • Tabelow, Karsten
    ORCID: 0000-0003-1274-9951

2010 Mathematics Subject Classification

  • 62P10 92C55 62G05

Keywords

  • Structural adaptive smoothing, diffusion weighted imaging, diffusion tensor model, Rician bias, software

Abstract

Diffusion Weighted Imaging has become and will certainly continue to be an important tool in medical research and diagnostics. Data obtained with Diffusion Weighted Imaging are characterized by a high noise level. Thus, estimation of quantities like anisotropy indices or the main diffusion direction may be significantly compromised by noise in clinical or neuroscience applications. Here, we present a new package dti for R, which provides functions for the analysis of diffusion weighted data within the diffusion tensor model. This includes smoothing by a recently proposed structural adaptive smoothing procedure based on the Propagation-Separation approach in the context of the widely used Diffusion Tensor Model. We extend the procedure and show, how a correction for Rician bias can be incorporated. We use a heteroscedastic nonlinear regression model to estimate the diffusion tensor. The smoothing procedure naturally adapts to different structures of different size and thus avoids oversmoothing edges and fine structures. We illustrate the usage and capabilities of the package through some examples.

Appeared in

  • J. Statist. Software, 31 (2009) pp. 1--24.

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